Basketball Junkie by Chris Herren and Bill Reynolds Essay Example for Free

Basketball Junkie by Chris Herren and Bill Reynolds Essay The book â€Å"basketball Junkie† is a Fantastic book it really is. This book is about a hometown high school superstar named Chris Herron on his journey from Fall River Massachusetts all the way to the Boston garden. Chris lived the dream of every kid who has ever bounced a basketball in their drive way. His accomplishments I believe is what really dragged me into the story. Just the fact that he wasn’t just an ordinary junkie from the streets that wrote a memoir. He was a basketball player that made it to the pros. I feel that gave it the edge just being up there compared to the best players such as Allen Iverson Jermaine o Neil and Kobe Bryant. Basketball Junkie was truly was an interesting story. Chris put it all out there. Herren talks about his substance abuse in brutally honest detail. He describes how his drug addictions caused him his basketball career and almost his life. How his NBA trip was short live as he spent more time chasing his next drug buy then working on his jump shot. Chasing what started out as Alcohol then to coke then to oxy cotton then to heroin caused his NBA career to fizzle out. How I related to the story was basically the same the story was told expect from another view. I witnessed a great basketball not as big as Chris Herren but good enough to get his name out there and play college basketball. This kid was great just like Chris a good person with many thing ahead in his life. Toward the end of his senior year I don’t know what you would call it. But I would say going down the wrong hanging with wrong crowd. That when he made the same mistake Chris made when he started. One thing lead to another just like Chris said in the book trying it once opened doors to other drugs. Unfortunately neither this kid nor Chris was able to close these doors. This was upsetting to watch so I could just imagine for a big superstar like this one. What there brothers were going through and the people who watched and taught Chris how to play. His coaches and people that helped Chris build up to this must have been so heartbroken. This story was really deep because you can tell that he wasn’t very appreciative of his life and accomplishments. He tells his nightmare on no matter what was going on he would always have to put his addiction first because the drug made him feel as if he couldn’t function otherwise. He also talks about his all-time low but I will let you figure out what that is in the book. This really made me feel bad for him. He wanted to be better but he couldn’t. Chris herren were stuck in a decade long nightmare of addiction. That ruined him causing him to get seven felonies and to overdose four times in his life time. One time his addiction actually leaving him dead for thirty seconds long. Overall I really enjoyed â€Å"Basketball Junkie†. I felt like in really brought me inside the life of a junkie addicted to drugs. He really put it out there. He gave his inside thoughts and feeling and how he needs drugs to function. Chris Herren saying this meant a lot even he was this big time basketball player in rolling stone, sport illustrator and all that. He still manages to get caught up in this lifestyle. â€Å"Basketball Junkie† inspired me to never take any chances for granted and to never let bad influences to get in between my future.

Thyroid Gland And Thyroid Hormone Synthesis

Thyroid Gland And Thyroid Hormone Synthesis Hypothyroidism is a condition characterized by abnormally low amount of the thyroid hormone synthesis. This may be due to a thyroid problem or any other reason. Thyroid hormone affects growth, development, and many cellular processes. Inadequate thyroid hormone has many consequences for the body Thyroid gland and thyroid hormone synthesis Thyroid gland has two lobes connected by an isthmus. It attaches to the thyroid cartilage and trachea. Therefore it moves with swallowing. Thyroid gland consists of follicles lined by a cuboidal epithelial cell layer. These follicles filled with colloids.Parafollicular cells situated in between follicular cells which secrete calcitonine. Thyroid gland synthesizes mainly two hormones. They are L-thyroxin/tetraiodothyronine (T4) and triiodothyronine (T3).T3 is the active form that acts at the cellular level and T4 is the prohormone.Iodide enters the thyroid follicles primarily through a transporter. Thyroid hormone synthesis occurs in the follicular space through a series of reactions, many of which are peroxides-mediated. Thyroid hormones stored in the colloid in the follicular space that is released from Thymoglobulin by a hydrolysis reaction which occur inside the thyroid cell. E.g. Thyroglobulin (Tgb), monoiodotyrosine (MIT), diiodotyrosine (DIT), Triiodothyronine (T3), tetraiodothyronine (T4). If there is hereditary defect of enzyme in above process, Thyroid hormone synthesis could not occur. So its leads to congenital goiter and often results in hypothyroidism. Regulation of the synthesis of thyroid hormones Thyroid hormone synthesis is regulated by another gland located in the brain called pituitary. In turn the pituitary gland in part regulated by the thyroid hormone via feedback mechanism and other gland called hypothalamus. The hypothalamus secretes thyrotropin hormone (TRH), which give a signal to the pituitary gland to release thyroid stimulating hormone (TSH). TSH in turn sends a signal to the thyroid gland to release thyroid hormone. If some defect occurs in one of these levels, a lack of production of thyroid hormones can cause a deficiency of thyroid hormone (hypothyroidism). Hypothalamus TRH down arrow Pituitary- TSH down arrow Thyroid- T4 and T3 The rate of thyroid hormone synthesis is regulated by the pituitary gland. If there is an insufficient amount of thyroid hormone circulating in the body to normal functioning, the release of TSH from the pituitary increased in order to stimulate more thyroid hormone. However, when there is a large amount of thyroid hormones in circulation, TSH level decreases and pituitary attempts to reduce the production of thyroid hormone. In people with hypothyroidism have low levels of circulating thyroid hormones. Physiological effects of thyroid hormones à ¢-   Cardiovascular system increased cardiac output and heart rate. à ¢-   skeletal system increased bone turnover and resorption. à ¢-   Respiratory maintains normal hypoxic and Hypercapnic drive in respiratory centre. à ¢-   Gastrointestinal increases gut motility. à ¢-   Blood increases red blood cell 2, 3-BPG facilitating Oxygen release to tissues. à ¢-   Neuromuscular increases speed of muscle contraction and relaxation and muscle protein turnover. à ¢-  Metabolism of carbohydrates increases hepatic Gluconeogenesis/glycolysis and intestinal glucose Absorption. à ¢-   Metabolism of lipids increased lipolysis and Cholesterol synthesis and degradation. à ¢-   Sympathetic nervous tissue increases catecholamine Sensitivity and ÃŽÂ ²-adrenergic receptor numbers in heart, skeletal muscle, adipose cells and lymphocytes. Reduces cardiac ÃŽÂ ±-adrenergic receptors. If there is a defect in the synthesis or regulation pathways or thyroid lead to many disorders. They are mainly divided in two parts. They are hyperthyroidism and hypothyroidism. Hyperthyroidism, or an overactive thyroid, is the overproduction of thyroid hormones T3 and T4, and most often caused by the development of Graves disease which is an autoimmune disease in which antibodies are produced which stimulate the thyroid gland produces excessive amounts of thyroid hormones. This disease can lead to the development of toxic goiter due to the growth of the thyroid gland in response to the absence of negative feedback mechanisms. This is manifested by symptoms such as thyroid goiter, protruding eyes (exopthalmos), palpitations, excessive sweating, diarrhea, weight loss, muscle weakness and unusual sensitivity to heat. Appetite is increased. Classification of Hypothyroidism Hypothyroidism is often classified by association with the indicated organ dysfunction Type Origin Primary Thyroid gland The most common forms are Hashimotos thyroiditis which is an autoimmune disease and can be occur in radioiodine therapy for hyperthyroidism. Secondary Pituitary gland Occurs if the pituitary gland does not release enough thyroid-stimulating hormone (TSH) to stimulate the thyroid gland to produce enough thyroid hormones. Although not every case of secondary hypothyroidism has a clear-cut case, it is usually caused by damage to the pituitary gland, as by a tumor, radiation, or surgery. Secondary hypothyroidism accounts for less than 5% or 10% of hypothyroidism cases. Tertiary Hypothalamus Results when the hypothalamus fails to produce sufficient Thyrotropin-releasing hormone (TRH). TRH prompts the pituitary gland to produce thyroid-stimulating hormone (TSH). Hence may also be termed hypothalamic-pitu Autoimmune Atrophic (autoimmune) hypothyroidism. The most common cause of hypothyroidism and the associated with antithyroid auto antibodies leads to lymphoid infiltration Cancer and eventually atrophy and fibrosis. It has been six Times more common in women and the incidence increases with age. This can be associated with other autoimmune Diseases such as pernicious anemia, vitiligo and other endocrine disorders. In some cases, intermittent Hypothyroidism occurs when recovering from illness, antibodies which block the TSH receptor can sometimes be involved in the etiology. Hashimotos thyroiditis. This form of autoimmune thyroiditis, again, more common in women and the most common in the late. The average age is atrophic changes with regeneration, leading to the formation of goiter. This may be usually firm and Rubber but can vary from soft to hard. TPO antibodies very high amount (>1000 IU / L). Patients can be euthyroid or hypothyroid, but they can pass through the initial phase of the toxic Hashi toxicity, Levothyroxine therapy. The goiter may reduce the even if the patient does not Hypothyroid. Postpartum thyroiditis. Typically, this is a temporary phenomenon Observed after pregnancy. It can cause hyperthyroidism, Hypothyroidism or the two sequences. It is believed to cause changes in the immune system necesnecessary.In case of pregnancy, and histologically lymphocytic thyroiditis. The process is usually self-limiting, but when Conventional antibodies are there is a strong chance this procedure of permanent hypothyroidism. Postpartum Thyroiditis may be misdiagnosed as postnatal depression. Thyroid function test is done to detect this situation. Defects in hormone synthesis Iodine deficiency. Dietary iodine deficiency still exists in some areas as endemic goiter where goiter, occasionally massive is common. Patients may be euthyroid or hypothyroidism depending on the severity of iodine deficiency. The mechanism is considered borderline hypothyroidism leading to TSH stimulation and thyroid enlargement against iodine deficiency continues. Iodine deficiency is this still a problem in the Netherlands, the Western Pacific and South. East Asia for example, the mountainous regions of the Himalayas and Africa. Some countries affected by iodine deficiency, for example, China and Kazakhstan take measures providing iodine in salt, but others, such as Russia, have not yet done so. Of The 500 million with iodine deficiency in India about 2 million suffering from cretinism.Dyshormonogenesis is a rare disease is due to genetics. Defects in the synthesis of thyroid hormones, patients Develop hypothyroidism with goiter. One particular family Form is associated with sensorineural hearing loss due to the removal Mutation of chromosome 7, resulting in a defect Transporter Pendrin (Pendred syndrome author). Hypothyroidism causes many symptoms. The term myxedema refers to the accumulation of mucopolysaccharides.In the subcutaneous tissue. The classical pictures are Slow in working, dry hair, thick-skinned, deep voice, Weight gain, cold intolerance, bradycardia, and constipation. These features make the diagnosis easy. Milder symptoms, however, more common and difficult to distinguish from other causes Nonspecific tiredness. Many of the cases on the biochemical detection Screening Particular difficulties in diagnosis may occur in certain circumstances: à ¢-   Children with hypothyroidism may not classical Properties, but often have a slow growth rate, poor School performance and sometimes arrests of pubertal Development. à ¢-   Young women with hypothyroidism may not show obvious signs. Hypothyroidism is excluded in all Patients with oligomenorrhea / amenorrhea, Menorrhagia, infertility and hyperprolactinemia. à ¢-   the elderly show many clinical features that are difficult Distinct from normal aging. Investigation of primary hypothyroidism The Serum TSH is the examination of choice, a high TSH level Confirmed primary hypothyroidism. A low free T4 level confirms the hypothyroidism is (and is also essential for TSH to close a deficiency and clinical hypothyroidism is strongly suspected and TSH is normal or low).Thyroid and other organ-specific antibodies are present. Other exceptions are the following: à ¢-   Anemia, usually normochromic and normocytic In type but can macrocytic (sometimes this is by Associated pernicious anemia) or microcytic (in women, By menorrhagia) à ¢-   increased serum aspartate transferase levels, from Muscle and / or liver à ¢-   increased serum creatine kinase levels, with associated myopathy à ¢-   Hypercholesterolemia and hypertriglyceridemia à ¢-   Hyponatremia due to an increase in ADH and reduced Free water clearance. Treatment Replacement therapy with levothyroxine (thyroxine, that is to say, T4) is Data for life. The starting dose will depend upon the severity of the failure and the age and condition of the patient, especially their cardiac function: 100ÃŽÂ ¼g per day during the Young and fit, 50ÃŽÂ ¼g (up to 100ÃŽÂ ¼g after 2-4 weeks) for the small, old or weak. Patients with ischemic heart disease Illness an even lower initial dose, especially if the Hypothyroidism is a severe and prolonged. Most doctors Would then start with daily 25ÃŽÂ ¼g and performing serial ECG, increasing the dose at 3 to 4-week intervals as angina Not occur or worsen and the ECG is not Deteriorate. Monitoring The goal is to recover well within T4 and TSH The normal range. The adequacy of the replacement is reviewed Clinical and thyroid function tests after at least 6 weeks at a constant dose. If serum TSH remains high, the dose of T4 Should is increased in increments of 25-50 g Æ’Â ¬ the tests Repeated 6-8 week intervals until TSH returns to normal. Complete suppression of TSH should be avoided atrial fibrillation and the risk of osteoporosis. The usual The Maintenance dose is 100 to 150 g Æ’Â ¬ administered as a single daily Dose. An annual thyroid function test is recommended this is usually done in the first line, often assisted and in response to the district thyroid registers. Clinical improvement T4 cannot start 2 weeks or more and complete resolution of symptoms 6 months. The need for lifelong therapy should be emphasized and the possibility of other autoimmune endocrine disease development, Especially Addisons disease or pernicious anemia, Should be considered. During pregnancy, an increase of T4 Dosage of about 25-50ÃŽÂ ¼g is often necessary to maintain normal TSH and the need for replacement during optimal. Pregnancy is highlighted by the finding of the reduction of Cognitive function in children of mothers with elevated TSH during pregnancy. A few patients with primary hypothyroidism complain incomplete symptomatic response to T4 replacement. Combination T4 and T3 replacement is advocated in this Context, but randomized clinical trials show no consistent Benefit from the quality of life symptoms. Borderline hypothyroidism or Compensated euthyroidism Patients are often seen with a low-normal serum T4 levels and slightly elevated TSH values. Sometimes this follows surgery or radioactive iodine therapy when it can be reasonably seen as compensatory. Treatment with levothyroxine is normally recommended where the TSH is consistently above 10 mu / L, or if possible symptoms, high titers of thyroid Antibodies or lipid abnormalities are present. When the TSH is only marginally increased, the tests must be repeated three to six Months later. Conversion to overt hypothyroidism is more common in men or TPO antibodies are present in Practice, vague symptoms in patients with marginal Elevated TSH (less than 10 mu / L) rarely responds to treatment, However, a therapeutic trial of substitution may be required to confirm that the symptoms are not related to the thyroid gland. It is also is considered to be the best time (TSH level normalization, the ideal case, the former) Pregnancy, in order to avoid the side effects of the fetus.Myxedema coma severe hypothyroidism, especially in the elderly, may be with confusion and even coma. Myxedema coma is very rare. Low temperature is often there, the patient may have severe heart failure, hypoventilation, hypoglycemia, and hyponatriemia.The best treatment Controversial, there is no data, most doctors recommend T3 oral or intravenous injection, a dose of Æ’Â ¬2, and 5-5 grams every 8 hours then, such as the above-mentioned increase. High-dose intravenous cannot be used. Other measures, although there is no proof of Include: à ¢-   Oxygen (by ventilation if necessary) à ¢-   monitoring of cardiac output and pressure à ¢-   Gradual warming à ¢-   Hydrocortisone 100 mg intravenously 8-hour à ¢-   Glucose infusion to avoid hypoglycemia. Myxedema madness Depression is common in hypothyroidism but rarely with severe hypothyroidism in the elderly can the patient be said demented or psychotic, sometimes with prominent delusions. This may occur shortly after starting T4 replacement. Screening for hypothyroidism à ¢-   the incidence of congenital hypothyroidism is Approximately 1 in 3500 births. Untreated, severe Hypothyroidism produces permanent neurological and Intellectual damage (cretinism). Routine screening of the newborn with a bloodstain, like Guthrie test, a high TSH level as an indicator of primary detecting Hypothyroidism is efficient and cost effective; cretinism is prevented if T4 is started within the first few months of life. à ¢-   screening of elderly patients for thyroid dysfunction a low pick-up rate and is controversial and not currently recommended. However, patients who have undergone Thyroid surgery or radioactive iodine should receive Regular thyroid function tests, should be as those who Lithium or amiodarone therapy. Signs and symptoms early hypothyroidism is often asymptomatic, can have very mild symptoms. Subclinical hypothyroidism normal levels of thyroid hormones, thyroxin (T4) and triiodo thyronine (T3), moderate to high thyroid-stimulating hormone, thyroid stimulating hormone (TSH) conditions. TSH and low free T4 at a higher level; the symptoms are more obvious in clinical hypothyroidism. Hypothyroidism may be associated with the following symptoms: Early à ¢Ã¢â€š ¬Ã‚ ¢ cold intolerance, increased sensitivity to cold à ¢Ã¢â€š ¬Ã‚ ¢ Constipation à ¢Ã¢â€š ¬Ã‚ ¢ weight gain, water retention à ¢Ã¢â€š ¬Ã‚ ¢ bradycardia (low heart rate less than 65 times per minute) à ¢Ã¢â€š ¬Ã‚ ¢ Fatigue à ¢Ã¢â€š ¬Ã‚ ¢ decreased sweating à ¢Ã¢â€š ¬Ã‚ ¢ Muscle cramps and joint pain à ¢Ã¢â€š ¬Ã‚ ¢ dry, itchy skin à ¢Ã¢â€š ¬Ã‚ ¢ thin, brittle nails à ¢Ã¢â€š ¬Ã‚ ¢ Quick thoughts à ¢Ã¢â€š ¬Ã‚ ¢ depression à ¢Ã¢â€š ¬Ã‚ ¢ muscle tension difference (hypotonia) à ¢Ã¢â€š ¬Ã‚ ¢ female infertility and problems in the menstrual cycle Hyperprolactinemia and galactorrhea à ¢Ã¢â€š ¬Ã‚ ¢ elevated serum cholesterol Late à ¢Ã¢â€š ¬Ã‚ ¢ goiter à ¢Ã¢â€š ¬Ã‚ ¢ slow speech and a hoarse, breaking voice deepening of the voice can also be noticed. Reinke edema. à ¢Ã¢â€š ¬Ã‚ ¢ Dry puffy skin, especially in the face à ¢Ã¢â€š ¬Ã‚ ¢ Thinning of the outer third of the eyebrows (sign of Hertoghe) à ¢Ã¢â€š ¬Ã‚ ¢ Menstrual cycle abnormalities à ¢Ã¢â€š ¬Ã‚ ¢ Low basal body temperature à ¢Ã¢â€š ¬Ã‚ ¢ thyroid related depression Uncommon Impaired memory Impaired cognitive function (brain fog) and inattentiveness. A slow heart rate with ECG changes including low voltage signals. Diminished cardiac output and decreased contractility Reactive ( post-prandial) hypoglycemia Hair loss slow reflexes Anemia caused by impaired hemoglobin synthesis (decreased EPO levels), impaired intestinal iron and folate absorption or B12 deficiency from pernicious anemia Yellowing of the skin due to impaired conversion of beta-carotene to vitamin A (carotoderma) Difficulty swallowing(dysphagia) Shortness of breath with a shallow and slow respiratory pattern(dyphnea) Increased need for sleep Irritability and mood instability Impaired renal function with decreased glomerular filtration rate myxedema madness (a rare presentation) Decreased libido due to impairment of testicular testosterone synthesis Impairment of taste sensation and anosmia Puffy face, hands and feet (late, less common symptoms) Gynecomastia(enlarge breast tissue) Loss of hearing Diagnosis thyroid function test the only validation test diagnosis of primary hypothyroidism is thyroid stimulating hormone (TSH) and free thyroxin (T4) level. However, these levels can be varying without thyroid disease. High TSH levels, the thyroid gland does not produce enough thyroid hormone levels (primarily thyroxin (T4) and a small amount of iodine Thyroid three original leucine (T3)). However, measuring just TSH can diagnose secondary and tertiary thyroid function loss, resulting in the following recommended a blood test, if the TSH is normal hypothyroidism remains skeptical: Free triiodothyronine (ft3) Free thyroxin (ft4) Total T3 Total T4 Additionally, the following measurements may be needed: Free T3 from 24-hour urine catch Antithyroid antibodies for evidence of autoimmune diseases that may be damaging the thyroid gland Serum cholesterol which may be elevated in hypothyroidism Prolactin as a widely available test of pituitary function Testing for anemia, including ferritin Basal body temperature Exams and Tests A physical examination may reveal a smaller than normal thyroid gland, although sometimes the gland is normal size or even enlarged (goiter). The examination may also reveal: Brittle nails Coarse facial features Pale or dry skin, which may be cool to the touch Swelling of the arms and legs Thin and brittle hair A chest x-ray may show an enlarged heart. Laboratory tests to determine thyroid function include: TSH test T4 test Lab tests may also reveal: Anemia on a complete blood count (CBC) Increased cholesterol levels Increased liver enzymes Increased prolactin Low sodium Treatment the treatment of hypothyroidism is levorotatory forms of thyroxin (thyroid hormone) (L-T4) and triiodo thyroxin liothyronine (L-T3). Thyroxin is a name, and in the USA, the most common form of thyroxin tablets. Thyroxin is a doctor of the most common drugs, wherein a synthetic thyroid hormone predetermined. This medicine can improve symptoms of thyroid deficiency such as speech delay, lack of energy, weight gain, hair loss, dry skin, cold feeling. This will also help in the treatment of goiter. It can also be used to treat certain types of thyroid cancer, surgery and other medicines. Both synthetic and animal thyroid tablets available, and may be required in patients with the additional thyroid hormone. Daily doses of thyroid hormone, doctors can monitor blood pressure, in order to help ensure that the correct dose. Thyroxin is the best 30-60 minutes before breakfast, because some foods can reduce absorption. Calcium can interfere with absorption levothryoxine. Compared with water, t he coffee can be reduced about 30% of the absorption of thyroxin. Some patients may be anti-thyroxin, in fact, they do not have good absorption sheet to solve the problem by spraying. There are several different treatment options for thyroid replacement therapy: T4 only such treatment methods include supplementary levothyroxin separately, a synthetic form. This is the current standard treatment of mainstream medicine. A combination of T4 and T3 in This treatment method involves the combination simultaneously manage two synthetic L-T4 and L-T3. Dried thyroid extract Dried thyroid extract is an animal thyroid extract; the most common is from porcine sources. It is also a combination therapy, containing a natural form of L-T4 and L-T3. Dealing with controversial T4 T3 generation has been investigating the potential benefits, but has proved to be no conclusive combination therapy benefit. Laboratory Medicine Practice Guidelines in 2002, the the clinical biochemical state of the U.S. National Academy of Sciences during pregnancy: L-T4 dose should be increased (usually 50 micrograms / day) maintained at 0.5 ~ 2.0 mIU / L and serum serum TSH FT4 within the normal reference interval the upper third. Doctors tend to assume that if your TSH is in the normal range, sometimes defined as high as 5.5 MIU / L has no effect on fertility. But there is an approximately 1.0 MIU / L, TSH level in healthy pregnant women Subclinical hypothyroidism there are a series of biochemical and point thyroxin treatment, the typical treatment of hypothyroidism symptoms views. Reference range has been debated. As of 2003, the American Association of Clinical Endocrinologists (ACEE) that within the normal range of 0.3-3.0 MIU / L. There is always an excess risk of hyperthyroidism. Some studies suggest that subclinical hypothyroidism does not require treatment. In 2007, the Cochrane Collaboration, a meta-analysis found that, in addition to the no benefit of thyroid hormone replacement lipids and left ventricular function in 2002 meta-analysis checks whether subclinical hypothyroidism may increase the risk of heart disease increase, some of the parameters previously thought, a slight increase, and recommended to be updated for the current recommendations for further research with the end point of coronary heart disease. Replacement therapy the connection has been a slow release combination of T3 and T4, supporters will be able to thyroid dysfunction symptoms and functional quality of life. This is still a matter of debate, refused by the traditional medical community. Remember, the important thing when are taking thyroid hormone are: à ¢Ã¢â€š ¬Ã‚ ¢ do not stop taking the drugs, and when you feel better. Continue the medication completely guidance of a doctor. à ¢Ã¢â€š ¬Ã‚ ¢ If you change the brand of thyroid drugs, let your doctor know. Your levels may need to be checked. Some dietary changes can change your body absorb thyroid drugs. Contact your doctor, if you eat a lot of soy products, or in the high-fiber diet. à ¢Ã¢â€š ¬Ã‚ ¢ Thyroid medicine best on an empty stomach, and if any other drugs before one hour. à ¢Ã¢â€š ¬Ã‚ ¢ do not take the thyroid hormone supplement fiber, calcium, iron, multivitamins, aluminum hydroxide, sulfuric acid agent, colestipol, or in combination with a bile acid drugs. You start taking replacement therapy, the doctor tells you, if you have any symptoms of increased thyroid activity (hyperthyroidism), such as Palpitations Rapid weight loss Restlessness or shakiness Sweating Myxedema coma is a medical emergency; the thyroid hormone the body becomes very low. Intravenous replacement thyroid hormone and steroids. Some patients may need support therapy (oxygen, breathing assistance, fluid replacement) and intensive care. Outlook (prognosis) in most cases, thyroid levels to normal, and appropriate treatment. However, thyroid hormone replacement for the rest of life.Myxedema coma can result in death. Possible complications Hypothyroidism, myxedema coma, the most severe form is rare. This can be caused by infection, illness, exposure to cold, or certain medications in untreated hypothyroidism. The symptoms and signs of myxedema coma include: à ¢Ã¢â€š ¬Ã‚ ¢ room temperature à ¢Ã¢â€š ¬Ã‚ ¢ Reduce breathing à ¢Ã¢â€š ¬Ã‚ ¢ low blood pressure à ¢Ã¢â€š ¬Ã‚ ¢ hypoglycemia à ¢Ã¢â€š ¬Ã‚ ¢ unresponsive Other complications include: à ¢Ã¢â€š ¬Ã‚ ¢ Heart disease à ¢Ã¢â€š ¬Ã‚ ¢ Increased risk of infection à ¢Ã¢â€š ¬Ã‚ ¢ Infertility à ¢Ã¢â€š ¬Ã‚ ¢ abortion Untreated hypothyroidism are at increased risk: à ¢Ã¢â€š ¬Ã‚ ¢ gave birth to birth defects à ¢Ã¢â€š ¬Ã‚ ¢ heart disease, the higher the level of LDL (bad cholesterol) à ¢Ã¢â€š ¬Ã‚ ¢ heart failure Too much thyroid hormone treatment are at risk of angina or a heart attack, as well as the risk of osteoporosis(the bone thinning).

Essay on Jealousy in Much Ado About Nothing, Othello, and Winters Tale

Jealousy in Much Ado About Nothing, Othello, and Winter's Tale    The common thread of jealousy ties together the main plots in Much Ado About Nothing, Othello, and The Winter's Tale. In each of these plays, the main conflict is centered around some form of jealousy. While jealousy is the mutual, most prominent cause for turmoil in these plays, its effects on the characters, and ultimately the plots, is different in each case. This difference has much to do with the way in which the concept of jealousy is woven into each play, and what it is intended to accomplish. In Othello, the jealousy factor is deliberately introduced by Iago, with the precise intention of destroying those whom he feels have wronged him. Since it is intentionally used with malicious intent, it has catastrophic results. Iago himself is jealous of Cassio; he feels that he should have been appointed to Cassio's position by Othello, and since he wasn't he hates both Othello and Cassio. Iago channels the jealousy that Othello and Cassio have made him feel, and uses it against them in a hateful plan. Iago starts the process by planting the seeds of jealousy in Othello's mind, telling him Desdemona has been unfaithful. He then proceeds to cultivate the growing jealousy by feeding it with more lies, and twisting innocent events into situations which would serve his needs (his telling Othello that Cassio and Desdemona met in secret, and convincing him that Desdemona vied for Cassio's reinstatement as lieutenant because she loved him, for example). When the seeds had flourished, and Iago had succeeded in driving Othello mad with jealousy, Iago harvested his crop and convinced Othello to kill Desdemona. Othello's killing Desdemona would both rid Iago of Desde... ...l effects, and when the mistake of jealousy was revealed the problem was solved and every one could be happy. In each of these plays, jealousy is used as a means of producing a conflict and creating trouble in the lives of the characters. The jealousy in each play, although it is introduced in a different way, always involves a man being jealous of his wife (or fiancà ©e, in Hero's case) being unfaithful with another man. Whether he misinterpret something he sees, or believe slanderous lies, the man's jealousy builds until it forces him to do something to punish his unfaithful woman. At the end of each play, the man is made to realize his mistake, but sometimes the damage can not be undone. Jealousy is the main crisis in each type of play - tragedy, trage-comedy, and comedy - but its results lie strictly in the way it is introduced, and the intended severity.   

Sir Francis Bacon :: essays research papers fc

Sir Francis Bacon   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Sir Francis Bacon was born January 22, 1561. He died April 9, 1626. He was an English essayist, lawyer, statesman, and philosopher . He had a major influence on the philosophy of science. When he was 12 years old, he began studies at Trinity College, Cambridge. In 1576 he entered Gray's Inn to pursue a career in law. He was first elected in 1584. Bacon's opposition to royal tax measures would probably have brought an end to his political advancement, but he had the support of the Earl of Essex, whose prosecution for treason he later managed. He was knighted in 1603 after the succession of James I. Bacon and he became solicitor-general in 1609, attorney-general in 1613, lord keeper of the great seal in 1617, and lord chancellor in 1618; he was also created Baron of Verulam I 1618, and Viscount St. Albans in 1621. Bacon retained James's favor by steadfast defense of royal prerogative, but in 1621 he was found guilty of accepting bribes and was removed from his office. Retiring to Gorhambury, he devoted himself to writing and scientific work.   Ã‚  Ã‚  Ã‚  Ã‚  Philosophically, Bacon wrote marks such as the Instauratio Magna (Great Restoration), setting forth his concepts for the restoration of humankind to mastery over nature. It was intended to contain six parts: first a classification of sciences; second a new inductive logic; third a gathering of empirical and experimental facts; fourth examples to show the effectiveness of his new approach; fifth generalization derivable from natural history; and a new philosophy that would be a complete science of nature.   Ã‚  Ã‚  Ã‚  Ã‚  Bacon completed only two parts, however, the Advancement of Learning in 1605, later expanded as De Dignitate et Augmentis Scientiarum (On the Dignity and Growth of Sciences, 1620); and the Novum Organum (The New Organon, 1620), which was to replace Aristotle's Organon. Sciences were under the general headings of history, poetry, and philosophy. Their culmination was an inductive philosophy of nature, in which proposed to find the natural laws, of bodily action. To this end, he devised so-called tables of induction designed to discover such forms with the goal of mastery over nature.   Ã‚  Ã‚  Ã‚  Ã‚  Although Bacon was not a great scientist, he gave impetus to the development of modern inductive science.

The Significance of ?Xenia? Essay -- essays research papers

The Significance of â€Å"Xenia† Ancient Greece is known for its beautiful theaters and its skilled poets. One of the most famous ones at that time and famous even now is Homer. Nobody knows who he actually is but the works that he has created are far more than magnificent. The Odyssey and The Iliad are two poems that turned into myths, have actually been accepted as part of the history of the Greeks. The Odyssey is a story about a hero from the Trojan War who struggles to get home to his family and when he finally does he faces the suitors who he fights and defeats with the help of the gods and his son who he hasn't seen for around twenty years. The gradual development of the plot, the actual, end of the book is easily noticed. A big role in that development plays hospitality or as Homer calls it the xenia. Odysseus' journey on his way back to his island Ithaca contains numerous details about hospitality and what it is to be a good or a bad host. His voyage is based on the kindness and the warmth of the people . There are gods and humans, and giants that do not appreciate the hero but he deals with them and we meet with the actual plot of the story, his homecoming. Warmth and kindness are presented within every visit described in the book. Homer draws a very good picture of how guests are welcomed, what entertainment they are given and the way they are send on their way. The picture is filled with kindness and warmth. We could say that the kind of hospitality presented in the book is hardly seen today. The different steps of welcoming some one are really interesting. The host is bathed and fed right after his arrival no matter who he is. Hosts do not really present the question that identifies their guest until later on, after he has been well rested and entertained. A great example of this is when Telemachos and Athene, in the body of Mentor, visit Nestor. When Nestor sees the two men he has never seen before he has a feast with his sons and companions. In the sight of the strangers they all stand up and greet them. The first thing that is done is to find a place for the two guests on the table and to feed them. â€Å"When they had satisfied their appetite and thirst, Nestor, the Gerenian charioteer, said: ‘Now that our visitors have eaten well, it is the right moment to put some questions to them and enquire who they are?†(Book#3line ... ...e, son, and servants they abuse for so long. "You dogs!’ he cried. ‘You never thought to see me back from troy. So you fleeced my household; you raped my maids; you courted my wife behind my back though I was alive- with no more fear of the gods in heaven than of the human vengeance that might come. One and all, your fate is sealed.†(Book #22, lines 35-40) These are the words of Odysseus, mad with the destruction the suitors have caused to his home. He kills them all, right before they are about to eat. He kills Antinous right when he is about to drink from the wine. The suitors do not deserve the food that is being served to them because of their cruelty towards the host ,the hostess and their disloyalty to him and Ithaca The Odyssey is a book that grabs its reader with its story about Odysseus and his final homecoming. There would be no homecoming or he would have been home too late to save his wife and son from the â€Å"arrogant " suitors if there was not the good hospitality of the people he visits. Everybody Odysseus meets on his way has helped the story progress by their bad or good hospitality. Therefore xenia plays a very significant role in the plot of the story.

Cancellation of Agreement of Sale Dated: 18-12-2011

This deed of cancellation of agreement is made and executed on this _____ day of _________, ________ at Hyderabad, By & Between. The Greater Banjara co-operative Housing Society Ltd. bearing registration no. TAB-606 dated 7-7-2004 at Hyderabad, represented by the president of the society Mr. Santhosh Raja, S/o. Shri Bhupal goud and the secretary Mr. Subhash Reddy S/o. Late K. Srinivasa Reddy along with the society members (herein after called the â€Å"Vendors†) which terms shall mean and include their legal representatives, auditors managing committee members, General members of the society and their nominees etc. and assigns in Vendor. AND 4 GEMS RELATOR’S AND DEVELOPERS Office: C/o. Raj Bhavan Road plot no. 134, Suyog Nagar, Nagpur – 4400013, Represented by its partners, PARHEEZ. S. GIMI, Aged 41yrs, R/o. Behramhi Town Nagpur, BHARAT. S. MESHRAM, Aged 38yrs, R/o. Shivaji Complex, Mankapur, Nagpur, ASHFAQ. SAMNANI, Aged 40yrs, R/o. C. A. Road, Nagpur. JOINTLY A ND SEVERALLY (Herein after called the â€Å"vendee†) which terms shall mean and include their heirs, legal representatives and assigns in Vendee. Whereas the Greater Banjara co-operative Housing Society Ltd, the VENDOR of the first part is a society registered under the provisions of Andhra Pradesh co-operative societies at 1964 and has been issued certificate of registration under section 8 of APCS act-VII of 1964 on 07-07-2004. the object of the said society is to carry on the trade and business of building, buying and selling the land is accordance with co-operative principles and with prior permission and authorization by its members as per the terms of bye-laws. Whereas the vendees of the second part are the residents of Nagpur city in the state of Maharashtra and are involved in the business including the business relating to sell purchase of agricultural and non agricultural lands and infrastructures and were in search of property for making investment and development as for its wish and whims. The vendees of the second part came in contact with vendor of the first part through concerned person and got knowledge about the intension of the vendors of the first part to sell and dispose of the said land. The vendees of the second part hence has shown their willingness to purchase the aforesaid land to which the vendors of the first part has consented. The vendors of the first part after making enquiry about business, personals and statues of vendees of the second part has entered into due discussions and deliberation and agreed to sell the aforesaid land to vendees of the second part on the agreed terms and conditions narrated in the agreement of sale. Where as both the Vendors and Vendees have entered into an agreement of sale dt. 18-12-2011, in respect of the property to an extent of Ac. 5. 36 guntas situated at road no. 12, Banjara Hills, Hyderabad. In this context the Vendee have issued three cheques vide nos. 078604, 078605 and 665088 dt. 19th, 20th and 23rd December 2011, respectively, for Rs. 5,00,000,00/- Cr. (Five Crore) of each, thus the total amount of Rs. 15, 00,000,00/- (Fifteen Crore) towards the advance part of sale consideration. Where as the Vendor has presented the above mentioned three cheques to the bankers of the vendees of Nagpur, as per scheduled dates through the bankers of vendors (i. e. ,) Indian Bank, Narayanaguda Branch, Hyderabad for collection, but it is very unfortunate that the Vendee has not honoured the above cheques, hence all the cheques were bounced. Where as the Vendor along with their well-wishers, Arbitrators, and consultants, discussed the matter seriously and felt very bad, about the behaviour and attitude of the vendees and decided to cancel and terminate the agreement of sale dt: 18-12-2011. Where as the Vendee expressed their inability to continue in the said contract and not in a position to fulfill the terms and conditions of their part, including to mobilize and arrangement of funds for purchase of the said scheduled property as per the agreement of sale dt:18-12-2011 and requested the vendors for cancellation of the above agreement of sale with due apologies to the vendors and their general members. Where as the vendors, as per the request and decision of the vendees and as per the instructions of the Arbitrators & Consultants, both vendors and vendees unanimously agreed and with full will and consent, cancelled and terminated the agreement of sale dt. 18-12-2011, thus the said agreement of sale has no valid and null and void. IN WITNESS WHERE OFF BOTH THE VENDORS AND THE VENDEES HAVE SIGNED THIS CANCELLED AGREEMENT OF SALE ON THE DAY, MONTH AND YEAR ABOVE MENTIONED IN THE PRESENDE OF THE FOLLOWING WITNESSES: Consultants: 1. 2. 3. 4. 5. 6. Witnesses: 1. 2.

Ekg Measurement and Interpretation at Rest and During Exercise

EKG Measurement and Interpretation at Rest and During Exercise Jonathan Murdock March 5, 2013 March 19, 2013 (KIN 375) Purpose: In the United States, people suffer from heart problems every day. According to the Centers of Disease Control and Prevention (CDC), every year about 935,000 people in the United States suffer from a heart attack and about 600,000 die from heart problems. Electrocardiograms (EKG or ECG) provide important information concerning the electrical activity of the heart as well as the quantity and quality of heart contractions.An EKG, along with blood work to measure troponin levels, can definitively determine whether or not a person has suffered from a myocardial infarction. In order to obtain an EKG, electrodes are strategically placed on the limbs and torso of a subject to measure the electrical current that is generated in the heart and transferred to the skin. The electrical signal is first generated in the sinoatrial node (SA node). It then travels to both th e left and right atria to cause them to contract.Then, the signal goes to the atrioventricular node (AV node) where it is briefly delayed to allow all of the blood from the atria to move into the ventricles. It then moves through the Bundle of His toward the apex of the heart and then through the Purkinje fibers. This causes contraction of the ventricles to pump blood throughout the body and lungs. The purpose of this lab was to compare EKG at rest with and exercising EKG. In doing so, the subject’s heart health could be determined based on the results of being put under the stress of exercise versus when resting.Methods: Subject: The subject participating in this lab was a college aged (18-25 years) male enrolled in KIN 375. The participant was healthy, exercised regularly, and did not report any history of heart problems. Equipment: The equipment used in this lab included alcohol prep wipes, 10 electrodes and wires, a computer to read the EKG with paper to print EKG strips, a chair, a treadmill, and a timer. Procedures: The first step was to remove the subject’s shirt.Next, all of the areas where electrodes were going to be placed were cleaned with an alcohol prep wipe. Once these areas were dry, electrodes were placed in their proper places; one electrode per limb and six on the torso. The electrodes for the left (LA) and right (RA) upper limbs were placed just under the clavicles near the shoulders. The electrodes for the left (LL) and right (RL) lower limbs were placed at the waist line just above each limb. For the torso, electrode 1(V1) was placed in the fourth intercostal space to the right of the subject’s sternum.Electrode 2 (V2) was also placed in the fourth intercostal space but to the left of the subject’s sternum. Next, electrode 4 (V4) was placed in the fifth intercostal space on the midclavicular line. Then, electrode 3 (V3) was placed halfway between V2 and V4. Next, the sixth electrode (V6) was placed in the fifth intercostal space on the midaxillary line. Lastly, the fifth electrode (V5) was placed halfway between V4 and V6 in the fifth intercostal space. The subject sat on the chair without moving for three minutes to generate a resting EKG.Then, the subject walked 2 mph on the treadmill with a 7. 0% incline for five minutes. This generated an exercising EKG. Lastly, the subject sat on the chair without moving for three minutes to generate a recovery EKG. Results: The subject successfully completed all three EKG recordings. The resting and recovery EKG readings were very easy to read; whereas, the exercising EKG had a lot of artifact that made it difficult to read. Artifact is something that is not â€Å"heart made† and usually comes from movement.The exercising EKG also had the most QRS complexes due to the fact that the subject’s heart rate was the highest while exercising. Discussion: As previously stated, an EKG measures the electrical currents of the heart. There are diff erent waves shown on an EKG. Each wave is represented by a letter. The first small wave is known as the P wave. The P wave represents atrial depolarization and contraction. The next wave is slightly negative and it is known as the Q wave. The Q wave initiates depolarization of the ventricles.The next wave, which is the large positive spike in the wave, is known as the R wave. The R wave represents ventricular depolarization and contraction. The next wave is slightly negative and it is known as the S wave. The S wave represents the negative wave of ventricular depolarization. The last wave is slightly larger than the P wave and it is known as the T wave. It represents ventricular repolarization and relaxation. Since there are three waves that represent ventricular depolarization, they are combined into what is known as the QRS complex.The section of the EKG from the beginning of the P wave to the beginning of the QRS complex represents the ventricular fill time and is known as the PR interval. Ventricular systole, or contraction, is shown by the start of the Q wave to the start of the T wave and is known as the QT interval. Lastly, from the end of the S wave to the start of the T wave, ventricular repolarization is normally isoelectric (on the baseline) and is represented by the ST segment. Any slight changes from normal sinus rhythm in any of these waves could indicate a heart problem.Electrodes were used to measure the electrical current in the heart. The paths from each electrode to another created a lead. Lead I was the path between RA and LA. Lead II was the path between RA and LL. Lead III was the path between LA and LL. The ground electrode was RL. An EKG wave read positive when the current moved toward a positive electrode and it read negative when the current moved toward the negative electrode. At rest, the EKG was much â€Å"cleaner† (less artifact) and the P waves, QRS complexes, and T waves were much easier to identify.During exercise, howev er, these waveforms were much more difficult to identify because of the large amount of artifact. Compared to at rest, the waveforms were much steeper and quicker which indicated the heart rate was speeding up, contraction and filling times decreased, and the contractions were much more forceful to pump the blood to the necessary tissue. There were a couple factors that could have hindered a completely accurate EKG reading; such as, cheap electrodes, movement of wires, and the placement of electrodes.All of these factors could have affected the EKG reading to cause extra artifact or inaccurate readings of the electrical current. Conclusion: Every year, hundreds of thousands of people die from heart problems. Many of these heart problems could be detected if the individuals had received an EKG. An EKG measures the electrical currents of the heart and shows when there are defects or blocks by the change in waveform. If more people were able to have an EKG when the problems arose, then maybe more lives would have been saved.